{"id":592,"date":"2020-12-07T11:30:55","date_gmt":"2020-12-07T11:30:55","guid":{"rendered":"https:\/\/hic.nihr.ac.uk\/?page_id=592"},"modified":"2025-11-20T16:54:34","modified_gmt":"2025-11-20T16:54:34","slug":"publications","status":"publish","type":"page","link":"https:\/\/hic.nihr.ac.uk\/publications","title":{"rendered":"Publications"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">Cardiovascular<\/h3>\n\n\n\n<p><strong>23 November 2019<\/strong> Troponin level, age and mortality risk in an unselected population of over 250000 patients \u2013 TROP-RISK study. An overview of the study can be found&nbsp;on the <a href=\"https:\/\/www.imperial.ac.uk\/news\/194029\/small-rise-heart-attack-protein-linked\/\">Imperial College London website<\/a>; the full paper can be found on the&nbsp;<a href=\"https:\/\/www.bmj.com\/content\/367\/bmj.l6055\" target=\"_blank\" rel=\"noreferrer noopener\">BMJ&nbsp;website<\/a>. <\/p>\n\n\n\n<p><strong>26 March 2020<\/strong> Prognostic significance of troponin level in 3121 patients presenting with atrial fibrillation (The NIHR Health Informatics Collaborative TROP-AF study)\u2019 is available on the <a href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.119.013684\">JAHA website<\/a>. <\/p>\n\n\n\n<p><strong>27 August 2020<\/strong> Invasive versus non-invasive management of elderly patients with non-ST elevation myocardial infarction (SENIOR-NSTEMI): a cohort study based on routine clinical data is available on&nbsp;<a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(20)30930-2\/fulltext\">The Lancet<\/a>&nbsp;website. An overview of the paper titled&nbsp;<em>\u2018<\/em>Age no criterion for decisions on heart attack treatment \u2018&nbsp;can be found&nbsp;on the <a href=\"https:\/\/www.imperial.ac.uk\/news\/203033\/age-criteria-decisions-heart-attack-treatment\/\">Imperial College London website<\/a>.<\/p>\n\n\n\n<p><strong>22 February 2022<\/strong> Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study can be found in <a href=\"https:\/\/journals.plos.org\/plosmedicine\/article?id=10.1371\/journal.pmed.1003911\">PLOS Medicine<\/a>.<\/p>\n\n\n\n<p><strong>09 March 2022<\/strong> Prognostic Significance of Ventricular Arrhythmias in 13&nbsp;444 Patients With Acute Coronary Syndrome: A Retrospective Cohort Study Based on Routine Clinical Data (NIHR Health Informatics Collaborative VA\u2010ACS Study) can be found in the&nbsp;<a href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.121.024260\">Journal of the American Heart Association<\/a>.                    <\/p>\n\n\n\n<p><strong>26 April 2022<\/strong> Implications of elevated troponin on time-to-surgery in non-ST elevation myocardial infarction (NIHR Health Informatics Collaborative: TROP-CABG study) is available in the <a href=\"https:\/\/www.internationaljournalofcardiology.com\/article\/S0167-5273(22)00586-1\/fulltext\">International Journal of Cardiology.<\/a>     <\/p>\n\n\n\n<p><strong>06 June 2022 <\/strong>Prognostic significance of troponin in patients with malignancy (nihr health informatics collaborative trop-malignancy study) is available in <a href=\"https:\/\/heart.bmj.com\/content\/108\/Suppl_1\/A135.1\">BMJ Heart<\/a>.     <\/p>\n\n\n\n<p><strong>06 June 2022 <\/strong>Association between age, troponin level and mortality in patients presenting to hospital with acute pulmonary embolism (nihr health informatics collaborative trop-pe study) is available in <a href=\"https:\/\/heart.bmj.com\/content\/108\/Suppl_1\/A129.1\">BMJ Heart<\/a>.<\/p>\n\n\n\n<p><strong>06 June 2022 <\/strong>Association between troponin and mortality in acute stroke (nihr health informatics collaborative trop-stroke study) is available in <a href=\"https:\/\/heart.bmj.com\/content\/108\/Suppl_1\/A129.2\">BMJ Heart<\/a>.<\/p>\n\n\n\n<p><strong>22 December 2022 <\/strong>Developing informatics infrastructure to curate datasets using electronic health record data from five hospitals for translational cardiovascular research is available in the <a href=\"https:\/\/academic.oup.com\/ehjdh\/article\/3\/4\/ztac076.2794\/6957190\">European Health Journal &#8211; Digital Health<\/a>. <\/p>\n\n\n\n<p><strong>02 June 2023 <\/strong>Elevated troponin during hospital admission with infection associated with increased short and long-term mortality is available in <a href=\"https:\/\/heart.bmj.com\/content\/109\/Suppl_3\/A50\">BMJ Heart<\/a>.<\/p>\n\n\n\n<p><strong>06 November 2023<\/strong>The Relationship Between Cardiac Troponin in People Hospitalised for Exacerbation of COPD and Major Adverse Cardiac Events (MACE) and COPD Readmissions is available in the <a href=\"https:\/\/www.dovepress.com\/the-relationship-between-cardiac-troponin-in-people-hospitalised-for-e-peer-reviewed-fulltext-article-COPD\">International Journal of Chronic Obstructive Pulmonary Disease<\/a>. <\/p>\n\n\n\n<p><strong>21 May 2024<\/strong> Changes in the investigation and management of suspected myocardial infarction and injury during COVID-19: a multi-centre study using routinely collected healthcare data is available on the <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1406608\/full?&amp;utm_source=Email_to_authors_&amp;utm_medium=Email&amp;utm_content=T1_11.5e1_author&amp;utm_campaign=Email_publication&amp;field=&amp;journalName=Frontiers_in_Cardiovascular_Medicine&amp;id=1406608\">Frontiers in Cardiovascular Medicine website<\/a>.     <\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Colorectal Cancer<\/h3>\n\n\n\n<p><strong>14 July 2022<\/strong>  Establishing a colorectal cancer research database from routinely collected health data: the process and potential from a pilot study is available at <a href=\"https:\/\/informatics.bmj.com\/content\/29\/1\/e100535\">BMJ Health and Care Informatics.<\/a><\/p>\n\n\n\n<p><strong>21 September 2025 <\/strong>Supporting cancer research on real-world data: extracting colorectal cancer status and explicitly written TNM stages from free-text imaging and histopathology reports available at <a href=\"https:\/\/informatics.bmj.com\/content\/32\/1\/e101521\">BMJ Health and Care Informatics<\/a>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Critical Care<\/h3>\n\n\n\n<p><strong>21 December 2017<\/strong>  Critical care data processing tools available on the <a href=\"http:\/\/joss.theoj.org\/papers\/10.21105\/joss.00513\">JOSS website<\/a>. <br> <br><strong>01 January 2018<\/strong> Electronic Health Record Research in Critical Care: The End of the Randomized Controlled Trial? This paper can be found in the <a href=\"https:\/\/link.springer.com\/chapter\/10.1007%2F978-3-319-73670-9_50\">Annual Update in Intensive Care and Emergency Medicine 2018<\/a>.<br><br><strong>31 January 2018<\/strong> Critical Care Health Informatics Collaborative (CCHIC): Data, tools and methods for reproducible research: A multi-centre UK intensive care database available in the <a href=\"https:\/\/doi.org\/10.1016\/j.ijmedinf.2018.01.006\">International Journal of Medical Informatics<\/a>.<br><br><strong>14 November 2018<\/strong> Optimal intensive care outcome prediction over time using machine learning available on the <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0206862\">PLoS ONE website<\/a>.<br><br><strong>12 September 2019<\/strong> The Association between Supraphysiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients.&nbsp;A Multicenter Observational Cohort Study&nbsp;available on the <a href=\"https:\/\/www.atsjournals.org\/doi\/full\/10.1164\/rccm.201904-0849OC\">American Journal of Respiratory and Critical Care Medicine website<\/a>.<\/p>\n\n\n\n<p><strong>01 July 2021<\/strong> Descriptors of Sepsis Using the Sepsis-3 Criteria \u2013 A Cohort Study in Critical Care Units Within the U.K. National Institute for Health Research Critical Care Health Informatics Collaborative available on the&nbsp;<a href=\"https:\/\/journals.lww.com\/ccmjournal\/Abstract\/9000\/Descriptors_of_Sepsis_Using_the_Sepsis_3_Criteria_.95176.aspx\">Critical Care Medicine.<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Hearing Health<\/h3>\n\n\n\n<p><strong>29 July 2024<\/strong> Creating a health informatics data resource for hearing health research available on the <a href=\"https:\/\/bmcmedinformdecismak.biomedcentral.com\/articles\/10.1186\/s12911-024-02589-x#:~:text=Results,record%20systems%20to%20research%20systems.\">BMC Medical Informatics and Decision Making website<\/a>.  <\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Infectious Diseases<\/h3>\n\n\n\n<p><strong>20 November 2019&nbsp;<\/strong>Evaluating a digital sepsis alert in a London multisite hospital network: a natural experiment using electronic health record data available on the <a href=\"https:\/\/academic.oup.com\/jamia\/article\/27\/2\/274\/5607431\">JAMIA website<\/a>. <\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Renal Disease<\/h3>\n\n\n\n<p><strong>01 February 2018<\/strong> Long\u2010 and short\u2010term outcomes in renal allografts with deceased donors: A large recipient and donor genome\u2010wide association study available in the <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/ajt.14594\">American Journal of Transplantation<\/a>.<\/p>\n\n\n\n<p><strong>22 July 2022<\/strong> Incidence, Risk Factors, and Effect on Allograft Survival of Glomerulonephritis Post-transplantation in a United Kingdom Population: Cohort Study&nbsp;available at&nbsp;<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneph.2022.923813\/full\">Frontiers in Nephrology<\/a>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Viral Hepatitis<\/h3>\n\n\n\n<p><strong>25 June 2019<\/strong> Electronic Health Informatics Data To Describe Clearance Dynamics of Hepatitis B Surface Antigen (HBsAg) and e Antigen (HBeAg) in Chronic Hepatitis B Virus Infection available on the <a href=\"https:\/\/mbio.asm.org\/content\/10\/3\/e00699-19\">American Society for Microbiology (MBio) website.<\/a><\/p>\n\n\n\n<p><strong>14 October 2020<\/strong> Bimodal distribution and set point HBV DNA viral loads in chronic infection: retrospective analysis of cohorts from the UK and South Africa available on <a href=\"https:\/\/wellcomeopenresearch.org\/articles\/5-113\/v2\">Wellcome Open Research.<\/a><br><br><strong>19 November 2020<\/strong>  National Institute for Health Research Health Informatics Collaborative: development of a pipeline to collate electronic clinical data for viral hepatitis research.  An overview of the paper can be found&nbsp;on the <a href=\"https:\/\/oxfordbrc.nihr.ac.uk\/key-step-for-hepatitis-research-as-patient-database-created\/\">NIHR Oxford BRC website<\/a>; full paper can be found on the&nbsp;<a href=\"https:\/\/informatics.bmj.com\/content\/27\/3\/e100145\">BMJ Health and Care Informatics website<\/a>.<\/p>\n\n\n\n<p><strong>30 April 2021<\/strong> Longitudinal Analysis of the Utility of Liver Biochemistry as Prognostic Markers in Hospitalized Patients With Corona Virus Disease 2019 available at&nbsp;<a href=\"https:\/\/aasldpubs.onlinelibrary.wiley.com\/doi\/10.1002\/hep4.1739\">Hepatology Communications.<\/a><\/p>\n\n\n\n<p><strong>26 June 2021<\/strong> Hepatitis B virus (HBV) viral load, liver and renal function in adults treated with tenofovir disoproxil fumarate (TDF) vs. untreated: a retrospective longitudinal UK cohort study&nbsp;available at&nbsp;<a href=\"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-021-06226-0\">BMC Infectious Diseases.<\/a>&nbsp;<\/p>\n\n\n\n<p><strong>11 February 2022<\/strong> Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK available at&nbsp;<a href=\"https:\/\/wellcomeopenresearch.org\/articles\/7-51\/v1\"><\/a><a href=\"https:\/\/wellcomeopenresearch.org\/articles\/7-51\/v1\">Wellcome Open Research<\/a><strong>.<\/strong>&nbsp;<\/p>\n\n\n\n<p><strong>16 June 2022<\/strong> Cohort Profile: National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) Research Dataset available at <a href=\"https:\/\/academic.oup.com\/ije\/advance-article\/doi\/10.1093\/ije\/dyac127\/6609198?login=true\">International Journal of Epidemiology (IJE)<\/a><\/p>\n\n\n\n<p><strong>11 July 2023<\/strong> Patient Biochemistry and Treatment Need in Chronic Hepatitis B Virus Infection Across Three Continents: Retrospective Cross-Sectional Cohort Studies available at <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s40121-023-00824-y\">Infectious Diseases and Therapy<\/a><\/p>\n\n\n\n<p><strong>31 January 2025<\/strong> Distinct virologic trajectories in chronic hepatitis B identify heterogeneity in response to nucleos(t)ide analogue therapy available at <a href=\"https:\/\/www.jhep-reports.eu\/article\/S2589-5559(24)00233-7\/fulltext\">JHEP Reports<\/a><\/p>\n\n\n\n<p><strong>23 October 2025<\/strong> Hepatitis B Virus (HBV) Treatment Eligibility in the UK: Retrospective Longitudinal Cohort Data to Explore the Impact of Changes in Clinical Guidelines available at <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.70098\">Journal of Viral Hepatitis<\/a><\/p>\n\n\n\n<p><strong>20 November 2025<\/strong> Characterisation of People Living With Chronic Hepatitis B Virus Infection in England and Stratification by HBsAg Levels: A Cross-Sectional Study available at <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.70101\">Journal of Viral Hepatis<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cardiovascular 23 November 2019 Troponin level, age and mortality risk in an unselected population of over 250000 patients \u2013 TROP-RISK study. An overview of the study can be found&nbsp;on the Imperial College London website; the full paper can be found on the&nbsp;BMJ&nbsp;website. 26 March 2020 Prognostic significance of troponin level in 3121 patients presenting with atrial fibrillation (The NIHR Health<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-592","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/592","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=592"}],"version-history":[{"count":48,"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/592\/revisions"}],"predecessor-version":[{"id":1201,"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/592\/revisions\/1201"}],"wp:attachment":[{"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=592"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}