{"id":721,"date":"2021-06-28T08:59:54","date_gmt":"2021-06-28T08:59:54","guid":{"rendered":"https:\/\/hic.nihr.ac.uk\/?page_id=721"},"modified":"2022-03-10T10:13:10","modified_gmt":"2022-03-10T10:13:10","slug":"t","status":"publish","type":"page","link":"https:\/\/hic.nihr.ac.uk\/?page_id=721","title":{"rendered":"Transfusion Dependent Anaemias"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignright size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/hic.nihr.ac.uk\/wp-content\/uploads\/2021\/06\/TDA-1.png\" alt=\"\" class=\"wp-image-724\" width=\"272\" height=\"251\"\/><\/figure><\/div>\n\n\n\n<p>In the UK, there are approximately 14,000 patients with sickle cell disease (SCD),&nbsp;1,000 patients with thalassaemia (THAL) and&nbsp;2,000&nbsp;patients with&nbsp;myelodysplasia (MDS). Many of these patients depend on regular  treatment by blood transfusion to prevent a decline in their health or quality of life, although the extent of the dependence varies between individuals. Many other cohorts of patients are intermittently dependent on transfusion e.g. during a period of&nbsp;myeloablative&nbsp;chemotherapy.&nbsp;&nbsp;The&nbsp;health of many of these patients depends on access to and the need for blood transfusion, delivered in an emergency or as part of a long-term transfusion programme.&nbsp;&nbsp;Formation of antibodies&nbsp;(alloimmunisation)&nbsp;following blood transfusion is common and severe transfusion reactions can be life-threatening.&nbsp;At present, no real world data are collated on the complex and costly treatment pathways for&nbsp;transfusion dependent anaemias, including on transfusion requirements, optimal blood matching algorithms, clinical  practice, and complications.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Aims of the NIHR HIC<\/h3>\n\n\n\n<p>The project aims to extract data&nbsp;on transfusion dependent patients&nbsp;from existing electronic data sources in the England\u2019s major transfusion centres. <\/p>\n\n\n\n<p>In the first instance, the project will collate data from NIHR HIC trusts to populate a data repository and to demonstrate the utility of such data collation for addressing the biological, clinical and economic challenges outlined above.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Collaborating Centres<\/h4>\n\n\n\n<p>University College London Hospitals NHS Foundation Trust (Lead Centre)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the UK, there are approximately 14,000 patients with sickle cell disease (SCD),&nbsp;1,000 patients with thalassaemia (THAL) and&nbsp;2,000&nbsp;patients with&nbsp;myelodysplasia (MDS). Many of these patients depend on regular treatment by blood transfusion to prevent a decline in their health or quality of life, although the extent of the dependence varies between individuals. Many other cohorts of patients are intermittently dependent on<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":41,"menu_order":14,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-721","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/721","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=721"}],"version-history":[{"count":2,"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/721\/revisions"}],"predecessor-version":[{"id":728,"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/721\/revisions\/728"}],"up":[{"embeddable":true,"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/41"}],"wp:attachment":[{"href":"https:\/\/hic.nihr.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=721"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}